Monoclonal antibody to Cystatin C, clone 1G11, hIgG1

Catalogue #

R1-300-100

Name

Monoclonal antibody to Cystatin C, clone 1G11, hIgG1

Target

Recombinant cystatin C

Target Description

Recombinant Cystatin C protein produced by CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line.

Alternative Names

Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin, CST3

Uniprot ID

P01034

Clone

1G11

Class

hIgG1

Reactivity

Binds to cystatin C. Lack of cross-reactivity to cystatin SN (CST1), SA (CST2), S (CST4), D (CST5), and cystatin F (SCT7) was demonstrated using an Octet system.

Application

ELISA, CLIA

Protocol

Concentration

1 mg/ml

Buffer

PBS, pH 7.4, Proclin 0.05%

Related Products

Cystatin C antibody clone 1G11 has been identified as a recommended capture antibody with clone 3B2 (cat# R1-301-100). The antibody pair was additionally tested using diluted human serum samples.

Shipping

Shipped with blue ice.

Storage

Store at +2…+8°C.

Background

Cystatin C belongs to the cysteine protease inhibitor family, first described in 1968. It is a small protein (13.4 kDa) produced by all nucleated cells in the body and it is removed from the bloodstream by the kidneys. Therefore, cystatin C levels in body fluids are useful indication of how well the kidneys are functioning. In clinical settings, cystatin C is used as a biomarker for chronic kidney disease or renal failure. It is a more sensitive marker than the widely used serum creatine for measurement of glomerular filtration rate (GFR), as cystatin C concentration in the serum is not affected by sex, race, age nor muscle mass. In addition to its use in kidney disease, cystatin C levels have also been associated with increased risk of death and cardiovascular events, like heart failure, in elderly persons.