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Figure 1. CE-SDS virtual gel output (LabChip GX) for monoclonal antibody to HbA1c, clone 2G5 under non-reduced (NR, left) and reduced (R, right) conditions.
HPLC analytical SEC
Figure 2. HPLC analytical SEC
HPLC analytical SEC after 3 freeze-thaw cycles
Figure 3. HPLC analytical SEC after 3 freeze-thaw cycles.
Octet binding analysis
Figure 4. Octet BLI analysis, antibody was loaded on sensor for capture of HbA1c protein in different concentrations.
(for reference only; data shown are from a single production batch at release and may not be representative of other batches)
Catalogue #
R1-370-100
Name
Monoclonal antibody to HBA1c, clone 2G5, hIgG1
Target
Native HbA1c
Target Description
Native HbA1c purified from human erythrocytes
Alternative Names
Hemoglobin subunit alpha, alpha-globin, hemoglobin alpha chain, HBA1, HBA2, hemoglobin A1c, glycohemoglobin, glycated hemoglobin, hemoglobin subunit beta, beta-globin, hemoglobin beta chain
Uniprot ID
P68871
Clonality
Human monoclonal
Clone
2G5
Class
hIgG1
Reactivity
Binds to HbA1c
Application
ELISA, CLIA
Protocol
Concentration
1 mg/ml
Buffer
PBS, pH 7.4
Related Products
HBA1c antibody clone 2G5 has been identified as a recommended capture and detection antibody with clone 3F3 (cat# R1-372-100).
Shipping
Shipped on dry ice.
Storage
Store in -65...-85 °C. Avoid multiple freeze-thaw cycles.
Background
Hemoglobin A1c (HbA1c), glycohemoglobin or glycated hemoglobin, a pivotal biomarker in diabetes management, is a form of hemoglobin found in red blood cells. The formation of HbA1c occurs via a non-enzymatic glycation process, primarily through the reaction between glucose and the N-terminal valine residue of the beta chain of hemoglobin. The higher the blood glucose levels over time, the more glucose binds to hemoglobin, leading to an increase in the HbA1c percentage. This glycation process occurs naturally over the lifespan of red blood cells, which is approximately 120 days. HbA1c is extensively used in clinical practice as a marker of long-term glycemic control in individuals with diabetes mellitus. It provides a stable and reliable measure of average blood glucose levels over the preceding 2 to 3 months, offering a more comprehensive view compared to daily glucose monitoring. The standard unit for reporting HbA1c levels is in millimoles per mole (mmol/mol) of hemoglobin but is typically measured as a percentage of total hemoglobin. Elevated HbA1c levels are associated with an increased risk of diabetes-related complications, including cardiovascular disease, neuropathy, nephropathy, and retinopathy. Therefore, it serves as a predictive tool for assessing the likelihood of these complications.
This product is for research use only
TECHNICAL ASSISTANCE
Please refer any technical questions to
technical.support@icosagen.com
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