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Figure 1. CE-SDS virtual gel output (LabChip GX) for monoclonal antibody to IGFBP1, clone 5B9 under non-reduced (NR, left) and reduced (R, right) conditions.
Figure 2. HPLC analytical SEC of final product.
Figure 3. HPLC analytical SEC after 3 freeze-thaw cycles.
Figure 4. Octet BLI analysis, antibody was loaded on sensor for capture of IGFBP1 protein in different concentrations.(for reference only; data shown are from a single production batch at release and may not be representative of other batches)
Catalogue #
R1-290-100
Name
Monoclonal antibody to IGFBP1, clone 5B9, hIgG1
Target
Recombinant IGFBP1 protein
Target Description
Recombinant IGFBP1 protein produced by CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line.
Alternative Names
Insulin Like Growth Factor Binding Protein 1, IGFBP-1, placental protein 12, PP12, IGF-binding protein 1.
Uniprot ID
P08833
Clonality
Human monoclonal
Clone
5B9
Class
hIgG1
Reactivity
Binds to IGFBP1
Application
CLIA, ELISA
Protocol
Concentration
1 mg/ml
Buffer
PBS, pH 7.4
Related Products
IGFBP1 antibody clone 5B9 has been identified as a recommended capture antibody pair with clone 2C12 (cat# R1-288-100) and clone 5C3 (cat# R1-291-100).
Shipping
Shipped on dry ice.
Storage
Store in -65...-85 °C. Avoid multiple freeze-thaw cycles.
Background
IGFBP1, or Insulin-like Growth Factor Binding Protein 1, is a 25 kDa protein that belongs to the IGFBP family, which regulates the actions of insulin-like growth factors (IGFs). It is mainly produced and secreted by the liver and is involved in modulating biological activities of IGF-s by binding and sequestering them into the circulation, thereby influencing cell growth, proliferation, and metabolism. IGFBP1 plays a crucial role in regulating glucose and lipid metabolism and is associated with insulin resistance, type 2 diabetes, and metabolic syndrome, all of which contribute to the development of NAFLD. Additionally, its altered expression has been linked to certain cancers, such as breast, prostate, and ovarian cancer, indicating its potential as a diagnostic or prognostic marker in these diseases.
This product is for research use only
TECHNICAL ASSISTANCE
Please refer any technical questions to
technical.support@icosagen.com
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