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Figure 1. CE-SDS virtual gel output (LabChip GXII) for monoclonal antibody to Myoglobin, clone 8D5 under non-reduced (NR, left) and reduced (R, right) conditions.
Figure 2. Analytical SEC of final product.
Figure 3. HPLC analytical SEC after 3 freeze-thaw cycles.(for reference only; data shown are from a single production batch at release and may not be representative of other batches)
Catalogue #
R1-269-100
Name
Monoclonal antibody to Myoglobin, clone 8D5, hIgG1
Target
Native myoglobin protein
Target Description
Native myoglobin protein purified from human heart.
Alternative Names
MB
Clonality
Human monoclonal
Clone
8D5
Class
hIgG1
Reactivity
Binds to myoglobin.
Application
ELISA, CLIA
Protocol
Concentration
1 mg/ml
Buffer
PBS, pH 7.4, ProClin 0.05%
Related Products
Myoglobin antibody clone 8D5 has been identified as a recommended detection antibody with clone 8G9 (cat# R1-270-100) and as a capture antibody with clone 4B6 (cat# R1-270-100).
Shipping
Shipped with blue ice.
Storage
Store at +2…+8°C
Background
Myoglobin, an oxygen- and iron-binding protein with a molecular weight of 18 kDa, is abundantly present in skeletal and heart muscles. After myocardial injury, myoglobin is rapidly released into the bloodstream and can be detected after 30 minutes, making it a sensitive biomarker. In patients with acute myocardial infarction (AMI), myoglobin levels are Elevated and therefore, it has been used as a marker for early onset. In AMI patients the concentration of myoglobin in the bloodstream peaks at 12 hours and is removed by the kidney within 24 hours. Myoglobin is a non-specific biomarker and mostly used to exclude the diagnosis of AMI. Myoglobin antibodies are usually part of a multimarker panel with for example cTnI, cTnT and CK-MB.
This product is for research use only
TECHNICAL ASSISTANCE
Please refer any technical questions to
technical.support@icosagen.com
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