Monoclonal antibody to Procalcitonin, hIgG1-kappa (clone 14H11)

Catalogue #

R1-403-100

Name

Monoclonal antibody to Procalcitonin, hIgG1-kappa (clone 14H11)

Target

Recombinant hPCT protein

Target Description

Produced by CHO-based cell line (expressed by QMCF Technology).

Alternative Names

CALCA, CALC1

Uniprot ID

P01258

Clonality

Human monoclonal

Clone

14H11

Class

hIgG1

Reactivity

human PCT

Application

ELISA, CLIA

Protocol

Buffer

PBSpH 7.4

Related Products

PCT antibody clone 14H11 has been identified as a recommended detection antibody with clone 9D8 (cat# R1-400-100). The 9D8-14H11 antibody pair was additionally validated using human sepsis serum samples.

Shipping

Shipped on dry ice.

Storage

Store in -65...-85 °C. Avoid multiple freeze-thaw cycles.

Background

Procalcitonin (PCT) is a protein member of the calcitonin superfamily that holds immense potential as a diagnostic tool for sepsis. Sepsis, a critical global healthcare issue, triggers systemic inflammation throughout the body in response to microbial infection, ultimately leading to organ dysfunction. The rapid elevation of procalcitonin levels during an infection, coupled with its strong correlation with the severity of illness, positions it as an optimal biomarker for identifying bacterial infections. Furthermore, procalcitonin levels can be utilized not only for assessing response to antimicrobial therapy, but also for diagnosing secondary inflammations, identifying renal involvement in pediatric urinary tract infections. The CALC-1 gene encodes the precursor of procalcitonin, which consists of 116 amino acids. Through successive cleavages, three distinct molecules are formed: a 57-amino acid N-terminal fragment, a 32-amino acid calcitonin molecule, and a 21-amino acid katacalcin molecule. These intricate processes contribute to the functional diversity and complexity of procalcitonin within the body's biological systems.