Mouse monoclonal antibody to hBDNF (clone 3C11)

Catalogue #

327-100

Name

Mouse monoclonal antibody to hBDNF (clone 3C11)

Description

The 3C11 clone of anti-human BDNF mAb recognizes preferentially one epitope in the central part of the protein spanning from amino acids Ser145-Lys153.

Target

Human BDNF

Target Description

Recombinant mature human BDNF protein produced in E. coli

Alternative Names

Abrineurin, neurotrophic factor BDNF precursor form, proBDNF, hBDNF, Brain-Derived Neurotrophic Factor

Uniprot ID

P23560

Clonality

Mouse monoclonal

Clone

3C11

Class

mIgG1

Reactivity

human, mouse, rat, guinea pig

Application

ELISA, WB, IF

Protocol

Concentration

1 mg/ml

Buffer

PBS pH 7.4, with 0.1% sodium azide.

Shipping

Shipping in ambient conditions.

Storage

Store at -20 °C to -70 °C. Avoid multiple freeze-thaw cycles.

Background

Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity such as long-term potentiation. BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses.

References

Zunino, G. Messina, A. Sgadò, P. Baj, G. Casarosa, S. Bozzi, Y. Brain - derived neurotrophic factor signaling is altered in the forebrain of Engrailed-2 knockout mice.
Neuroscience. 2016 Mar 14