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Figure 1. Western Blot testing of anti-CDNF polyclonal antibody. Line 1. PageRuler Prestained Protein Ladder (#SM0671 Fermentas); Line 2. Recombinant CDNF expressed into the supernatant of CHO cell culture medium.
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B
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(for reference only; data shown are from a single production batch at release and may not be representative of other batches)
Catalogue #
300-100
Name
Rabbit polyclonal antibody to human CDNF
Target
Human CDNF
Target Description
Recombinant human CDNF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified from cell culture supernatant.
Alternative Names
ARMETL1, cerebral dopamine neurotrophic factor, ARMET-like protein 1, conserved dopamine neurotrophic factor
Uniprot ID
Q49AH0
Clonality
Polyclonal
Class
IgG
Reactivity
Human, mouse; others not tested
Application
ELISA, WB, IF, IHC
Protocol
Buffer
50% saturated ammonium sulfate in PBS
Shipping
Shipping in ambient conditions.
Storage
Store at +2 °C to +8 °C. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use
Background
CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
This product is for research use only
TECHNICAL ASSISTANCE
Please refer any technical questions to
technical.support@icosagen.com
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