Recombinant antibody to hGDF15, clone 6E2, hIgG1

Catalogue #

R1-219-100

Name

Recombinant antibody to hGDF15, clone 6E2, hIgG1

Target

Recombinant hGDF-15 protein

Target Description

Recombinant human GDF-15 protein produced by CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line.

Alternative Names

Growth differentiation factor 15, MIC-1, Macrophage inhibitory cytokine-1

Uniprot ID

Q99988

Clonality

Human monoclonal

Clone

6E2

Class

hIgG1

Reactivity

Binds to human GDF-15 protein.

Dissociation constant (K_D)

Summary of antibody screening to soluble recombinant GDF-15 using an Octet system.
KD, M: 1,15E-09

Application

ELISA

Protocol

Purification

Protein A affinity chromatography followed by gel filtration.

Purity

>90%

Concentration

1 mg/ml

Buffer

PBS pH 7.4

QC

Simply Blue Safe stained SDS-PAGE, analytical HPLC-SEC, Octet binding.

Related Products

No established recommended antibody pairing for this clone.

Shipping

Shipped on dry ice.

Storage

Store in -65...-85 °C. Avoid multiple freeze-thaw cycles.

Background

Growth differentiation factor 15 (GDF-15) is a cytokine that belongs to the transforming growth factor beta (TGF-β) superfamily. It is expressed in various tissues throughout the body, including the liver, placenta, and heart, and plays a pivotal role in regulating cell growth, differentiation, and survival. Elevated levels of GDF-15 have been associated with a variety of disease states, including cancer, cardiovascular disease and chronic kidney disease. In cardiovascular disease, increased levels of GDF-15 have been linked to an elevated risk of adverse outcomes, including heart failure, atherosclerosis, acute myocardial infarction and acute coronary syndrome.